Vaccination coverage in the US and Colorado remains mostly high and stable. However, for many vaccines, the US and Colorado fail to reach the Center for Disease Control (CDC) Healthy People (HP) 2030 targets, and Colorado falls below national averages for vaccine coverage. This report provides an overview of data from the National Immunization Survey (NIS), conducted annually by the CDC. It is important to note that in 2020, vaccination rates declined significantly, due in part to more limited healthcare access during the COVID-19 pandemic. This decline is not currently represented in this review.