Systemic racism continues to drive a serious public health crisis in Colorado and beyond, evidenced as COVID-19 has disproportionately impacted communities of color with Black, Hispanic and Native American communities experiencing higher rates of disease and death. At the same time, these communities have been increasingly targeted with misinformation about vaccine safety. To address this crisis and work toward vaccine equity, Immunize Colorado launched the Colorado Vaccine Equity Taskforce in 2020. The Taskforce, whose members represent communities of color and have expertise in a variety of areas - including advocacy, policy-making, business, faith-based leadership, public health, healthcare and infectious disease research -, prioritizes strategies for equitable immunization delivery, access and education, and implements efforts to reduce barriers to vaccination. Through outreach, policy and communications work in English and Spanish, the Taskforce also combats misinformation targeted predominately at communities of color about vaccines, informs research and implementation efforts for COVID-19 vaccines, and holds decision makers accountable for achieving vaccine equity in Colorado.